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ADIPEX is a adrenergic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity. Actions include elevation of blood pressure and central nervous system stimulation and. Tachyphylaxis and tolerance have been demonstrated with all the drugs of this class in which these phenomena have been looked for. Medications of this class used in obesity are commonly known as “anorectics” or “anorexigenics.” It has not been proven that the action of such drugs in treating obesity is primarily one of appetite suppression.
Adult obese subjects instructed in dietary management and treated with “anorectic” drugs lose more weight on the average than those patient treated with placebo and diet, as determined in relatively short-term clinical trials.
The magnitude of increased weight loss of drug-treated patients over placebo-treated patients is only a part of a pound a week. The rate of weight loss is at it’s peak in the first weeks of therapy for both drug and placebo subjects and tends to decrease in succeeding weeks. The possible origins of the increased weight loss is because of the various drug effects are not established. The amount of weight loss is related with the use of an “anorectic” drug varies from trial to trial, and the increased weight loss appears to be related in part to variables other than the drugs prescribed, such as the physician-investigator, the population treated and the diet prescribed. Studies do not permit conclusions as to the relative importance of the medication and non-drug factors on weight loss. The history of obesity is measured in years, whereas the studies cited are limited to a few weeks’ duration; thus, the total impact of drug-induced weight loss over that of diet alone must be considered clinically limited.
ADIPEX-Pis indicated as a short-term adjunct in a regimen of weight reduction based on exercise, behavioral modification and caloric restriction in the management of exogenous obesity for patients with an initial body mass index ≥30 kg/m2, or ≥27 kg/m2 in the presence of other risk factors.